解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::We have previously established a rat model of chronic uremia, which is suitable to investigate the effect of various treatment modalities on renal osteodystrophy [1]. After four months subsequent to 5/6 nephrectomy, some animals were treated by gavage for 9 weeks with tap water (controls), or with aluminium (Al-citrat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01201001
更新日期:1996-02-01 00:00:00
abstract::Whether they are small enough to wriggle through the current-carrying part of an ionic channel or big enough to be kept outside and thus able to exert an osmotic stress on the channel space, polymers interact with channels in several instructive ways. The osmotic stress of excluded polymers allows one to measure the n...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01204353
更新日期:1995-12-01 00:00:00
abstract::The coupling of the chemical reaction of ATP hydrolysis to the transport of calcium from the cytoplasm into the lumen of sarcoplasmic reticulum vesicles can be defined by a set of rules that define alternating changes in the specificities of the enzyme for catalysis of chemical and physical reactions. ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01788360
更新日期:1995-10-01 00:00:00
abstract::This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, o...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01788370
更新日期:1995-10-01 00:00:00
abstract::Gamma- and delta-isomers of hexachlorocyclohexane caused marked decreases in the levels of radioactive phospholipids, and increases in the levels of [3H]arachidonate incorporated into free fatty acids in rat renal tubular cells. The increased radioactivity of free fatty acids arises from the decrease of [3H]arachidona...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01540453
更新日期:1995-08-01 00:00:00
abstract::Polycationic amino acids induce the leakage and fusion of liposomes containing anionic lipids. We have investigated the nature and extent of the changes in membrane physical properties caused by these polypeptides which could result in the observed membrane destabilization. We found that in the range of pH 5 to pH 7 b...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01207455
更新日期:1995-06-01 00:00:00
abstract::Insulin stimulated a concentration-dependent increase in protein synthesis in L6 myoblasts which was significant at 1 nM. This response was not prevented by the transcription inhibitor, actinomycin D. The protein kinase C (PKC) inhibitor, Ro-31-8220, and downregulation of PKC by prolonged incubation of cells with 12-O...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01200213
更新日期:1995-02-01 00:00:00
abstract::The effect of sodium butyrate (NaBut) on cell growth was studied in normal rat kidney (NRK) fibroblasts, and in NRK cells stably transfected with either the adenoviral gene E1A (wild-type), or mutated E1A (E1Amut; with a deletion in the CR1 domain), or with the transforming Ha-ras (EJ) gene. The growth of all these ce...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01199053
更新日期:1994-12-01 00:00:00
abstract::Stimulatory GTP-binding Protein (Gs) and adenylate cyclase prepared from bovine brain cortices were co-reconstituted into asolectin vesicles with or without 1000-fold transmembrane Ca2+ gradient. The results showed that both basal activity and Gs-stimulated activity of adenylate cyclase were highest in proteoliposomes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01200247
更新日期:1994-08-01 00:00:00
abstract::Lung surfactant protein A (SP-A) is the most abundant surfactant-associated protein present in the lung. A receptor for SP-A has been shown to be present on A549 alveolar type II cells and on other cell types, including alveolar macrophage. The SP-A receptor on A549 cells has been identified as the collection receptor...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01145960
更新日期:1993-04-01 00:00:00
abstract::It is well known that the amino acids in the blood are distributed between the plasma and inside the cells. This study was conducted to determine whether amino acids can be located adsorbed on blood cell membranes. The amino acid concentration in the deproteinized haemolysed blood was higher than that in the fraction ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01136856
更新日期:1991-08-01 00:00:00
abstract::High-affinity binding of 3H-folate in Triton X-100 solubilized membranes of human liver displayed characteristics, e.g. apparent positive cooperativity, which are typical of specific folate binding. Ultrogel AcA 44 chromatography of solubilized membranes saturated with 3H-folate revealed a major peak of 100 kDa and a ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01182482
更新日期:1991-06-01 00:00:00
abstract::The influence of lindane upon the dynamic properties of plasma membranes from rat ventral prostate has been investigated using a fluorescence polarization technique. Preincubation with lindane decreased the fluorescence polarization in a dose dependent manner. This effect, which is associated with an increased membran...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119197
更新日期:1991-04-01 00:00:00
abstract::Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respirat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01118600
更新日期:1991-02-01 00:00:00
abstract::This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116615
更新日期:1990-12-01 00:00:00
abstract::Rat ventral prostate incorporated (1-14C)acetate, (1-14C)palmitate and (1-14C)linoleate into different phospholipids in a time-dependent process. The rate of incorporation into total phospholipids was higher with linoleate (10.0 nmol/g) than with either palmitate (5.8 nmol/g) or acetate (4.7 nmol/g). Predominant label...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116858
更新日期:1990-02-01 00:00:00
abstract::Extracts from uterine cervical and body cancers, but not from benign tumor or intact tissues tested, were found to contain a growth-promoting activity which induced the proliferation of human endometrial fibroblasts. Exposure of cultured fibroblasts to the cancer extracts increased the rate of [3H]thymidine incorporat...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116850
更新日期:1990-02-01 00:00:00
abstract::Myelin Basic Protein, one of the major membrane protein component of the central nervous system, was used to probe the molecular mechanism of cellular activation by phytohaemagglutinin. Pre-treatment of human lymphocytes with myelin basic protein results in a lower rising of cytosolic concentration of free calcium aft...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116851
更新日期:1990-02-01 00:00:00
abstract::Partitioning in charge-sensitive dextran-poly(ethylene glycol) aqueous phase systems reveals that fixation with even small concentrations of glutaraldehyde (e.g., 0.1% w/v) changes the surface properties of cells. While fixation with larger concentrations of glutaraldehyde (i.e., 1.85%) increases erythrocyte partition...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114811
更新日期:1989-12-01 00:00:00
abstract::Ehrlich Ascites Tumour cells were irradiated with UV-light to crosslink DNA to proteins in vivo. The DNA fragments associated with the nuclear lamina were purified and characterized. The results of the Cot analysis and the hybridization experiments suggest that the DNA fragments attached to the nuclear lamina although...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119802
更新日期:1989-10-01 00:00:00
abstract::Using a quantitative enzyme immunoassay, Thy-1 antigen expressed by a rat myoid cell line R615B2 was detected mainly on the cell surface at a single cell stage, whereas at the stage of forming myotubes, Thy-1 was found predominantly in the cytoplasm. The muscle specific creatine kinase activity also increased in assoc...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119804
更新日期:1989-10-01 00:00:00
abstract::Calmodulin-free ghost membranes were prepared from erythrocytes of kwashiorkor children and from healthy children in the same age bracket. In the absence of calmodulin, the specific activity of Mg2+-dependent Ca2+-pumping ATPase (Ca2+ + Mg2+-ATPase) of kwashiorkor membranes was more than 40 percent lower than the spec...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114689
更新日期:1989-06-01 00:00:00
abstract::Blood platelets have the capacity to participate in a number of physiological as well as pathological processes within the circulation. In order to evaluate their cellular reactivity a number of platelet function tests have been developed. The main in vitro function tests are assessment of aggregation and adhesion, se...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114683
更新日期:1989-06-01 00:00:00
abstract::BRL 26830 is a thermogenic beta-adrenoceptor agonist which stimulates lipolysis and fatty acid oxidation in vivo. It also stimulates insulin secretion, and hence promotes glucose utilisation in vivo. The effect of this agent on white and brown adipose tissue of the rat was investigated. BRL 26830 increased the rate of...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117517
更新日期:1989-02-01 00:00:00
abstract::The nature of certain forms of memory is discussed in relation to neural networks and REM sleep. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117331
更新日期:1988-12-01 00:00:00
abstract::The ways in which certain inorganic elements are used in essential roles within biological systems generally are described. The two roles stressed are (1) electrolytic charge movements and (2) electronic charge movement. The value of helical proteins inside and outside membranes as mechanical coupling devices is analy...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117344
更新日期:1988-12-01 00:00:00
abstract::Erythrocytes suspended in a medium of low ionic strength lyse under the effect of an exponential electrical pulse. The percentage of haemolysed cells decreases several-fold in the presence of divalent cations. The protective action of the ions studied increases in the following order: Ca++, Mg++, Zn++. It is assumed t...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01121639
更新日期:1988-10-01 00:00:00
abstract::In order to better understand the role of cell surface glycolipids in T lymphocyte activation, heparin was used to simultaneously modulate the expression of glycolipids and the lytic capacity of lymphocytes activated by interleukin-2. Results presented here show that heparin added at the start of a 3 day culture inhib...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01115230
更新日期:1988-08-01 00:00:00
abstract::Superoxide dismutase (SOD), a metal containing enzyme is present in parasite Leishmania donovani as well as in host macrophages both resident and activated in a detectable amount, although the level is much higher in the latter case. It is observed that at any particular protein concentration, the SOD activity is high...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116457
更新日期:1988-04-01 00:00:00
abstract::Triacylglycerol/fatty acid substrate cycling was measured in vivo in brown adipose tissue (BAT) and white adipose tissue (WAT) of fed, starved and refed rats. Starvation (24h) significantly decreased the rate of cycling in BAT, and refeeding chow diet led to a rapid, 6-fold increase in cycling. Cycling rate in WAT was...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116459
更新日期:1988-04-01 00:00:00
abstract::Gold thioglucose and gold sodium thiomalate were shown to be potent activators of latent human leukocyte collagenase. No activation by auranofin was noted. The activation may proceed through the action of gold on the essential sulfhydryl groups of latent enzyme and, thereby, mimick the action of the known organomercur...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122130
更新日期:1987-12-01 00:00:00
abstract::In rats fed a normal (22% protein) diet, injection of clenbuterol (1 mg/kg/d for 21 d) did not affect energy intake, energy expenditure or weight gain, but reduced energetic efficiency, and fat and energy gains and increased body protein content. Presenting a low-protein (8%) diet reduced energy intake, gain and effic...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01122126
更新日期:1987-12-01 00:00:00
abstract::Recent developments in the study of peptide amidation are reviewed. The main areas covered are assay procedures, purification of amidating enzymes, co-factors and regulation, mechanism and specificity of the amidating reaction, and multiple forms of the amidating enzyme and glycosylation. Discussion is presented on as...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01122123
更新日期:1987-12-01 00:00:00
abstract::Circulating human neutrophils exhibited low rates of protein biosynthesis, as determined by their ability to incorporate [35S]methionine into TCA-precipitable material. Exposure of cells to the chemotactic peptide (N-formyl-L-methionyl-L-leucyl-L-phenylalanine) increased their rate of protein synthesis, and the maxima...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119479
更新日期:1987-11-01 00:00:00
abstract::The effect of lysolecithin (lysophosphatidylcholine) on the relaxation of rabbit aortic strip closely resembled that produced by acetylcholine (ACh) which releases the endothelium-derived relaxing factor (EDRF). Relaxation induced by lysolecithin depended on the presence of endothelium and was inhibited by hemoglobin ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116751
更新日期:1987-10-01 00:00:00
abstract::A novel approach was used to assess the role of phosphoinositide hydrolysis in the mitogenic action of phytohemagglutinin (PHA) or concanavalin A (ConA). The treatment of human peripheral blood leukocytes (PBL) with monospecific antibodies against phospholipase C (PLC) produced a dose-dependent inhibition (up to 100%)...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116866
更新日期:1987-09-01 00:00:00
abstract::A riboflavin carrier protein has been purified from human pregnancy and umbilical cord sera by affinity chromatography and fast protein liquid chromatography. This protein has a similar molecular weight to the chicken egg riboflavin carrier protein and shares other physicochemical properties, such as pI and riboflavin...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01119773
更新日期:1987-07-01 00:00:00
abstract::The effects of E. coli endotoxin 0127 B8 on oxygen consumption, temperature, and on the activity of the proton conductance pathway in brown adipose tissue (BAT) were investigated in rats and mice. In rats an increase was observed in rectal and skin temperature, whole body oxygen consumption and GDP binding in BAT. In ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116509
更新日期:1987-06-01 00:00:00
abstract::The secretory process is a coordinated cellular response, initiated by occupation of surface receptors and comprising an ordered sequence of biochemical steps subject to multiple controls. Conceptually we can divide the sequence into two main sections comprising early, receptor-mediated events leading to generation of...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/BF01362501
更新日期:1987-05-01 00:00:00
abstract::Peptide sequencing of the complement system regulatory protein, factor H, permitted the synthesis of a mixed sequence oligonucleotide probe. Human liver cDNA libraries were screened and factor H-specific clones selected. No full-length clone was obtained, but the largest available clone, R2a, was found to encode the C...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01124790
更新日期:1987-03-01 00:00:00